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Cathepsin H
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| PDB rendering based on 1nb3. The Protein Data Bank ( PDB) is a repository for 3-D structural data of Proteins and Nucleic acids These data typically obtained by X-ray crystallography | ||
| Available structures: 1nb3, 1nb5, 8pch | ||
| Identifiers | ||
| Symbol(s) | CTSH; CPSB; ACC-4; ACC-5; DKFZp686B24257; MGC1519; minichain | |
| External IDs | OMIM: 116820 MGI: 107285 HomoloGene: 36159 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 1512 | 13036 |
| Ensembl | ENSG00000103811 | ENSMUSG00000032359 |
| Uniprot | P09668 | Q3UCD6 |
| Refseq | NM_004390 (mRNA) NP_004381 (protein) |
NM_007801 (mRNA) NP_031827 (protein) |
| Location | Chr 15: 77 - 77.02 Mb | Chr 9: 89.85 - 89.87 Mb |
| Pubmed search | [1] | [2] |
Cathepsin H, also known as CTSH, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. Two transcript variants encoding different isoforms have been found for this gene. [1]
References
Further reading
- Sawicki G, Warwas M (1990). "Cathepsin H from human placenta. ". Acta Biochim. Pol. 36 (3-4): 343–51. PMID 2486008.
- Fuchs R, Gassen HG (1990). "Nucleotide sequence of human preprocathepsin H, a lysosomal cysteine proteinase. ". Nucleic Acids Res. 17 (22): 9471. PMID 2587265.
- Chernaia VI, Reva AD (1990). "[Cathepsin H activity in the human brain and human brain neoplasms]". Ukr. Biokhim. Zh. 61 (5): 47–50. PMID 2588347.
- Fuchs R, Machleidt W, Gassen HG (1989). "Molecular cloning and sequencing of a cDNA coding for mature human kidney cathepsin H. ". Biol. Chem. Hoppe-Seyler 369 (6): 469–75. PMID 2849458.
- Ritonja A, Popović T, Kotnik M, et al. (1988). "Amino acid sequences of the human kidney cathepsins H and L. ". FEBS Lett. 228 (2): 341–5. PMID 3342889.
- Järvinen M, Rinne A (1983). "Human spleen cysteineproteinase inhibitor. Purification, fractionation into isoelectric variants and some properties of the variants. ". Biochim. Biophys. Acta 708 (2): 210–7. PMID 6184075.
- Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank. ". Gene 150 (2): 243–50. PMID 7821789.
- Baumgrass R, Williamson MK, Price PA (1997). "Identification of peptide fragments generated by digestion of bovine and human osteocalcin with the lysosomal proteinases cathepsin B, D, L, H, and S. ". J. Bone Miner. Res. 12 (3): 447–55. PMID 9076588.
- Söderström M, Salminen H, Glumoff V, et al. (1999). "Cathepsin expression during skeletal development. ". Biochim. Biophys. Acta 1446 (1-2): 35–46. PMID 10395917.
- Jokimaa V, Oksjoki S, Kujari H, et al. (2001). "Expression patterns of cathepsins B, H, K, L and S in the human endometrium. ". Mol. Hum. Reprod. 7 (1): 73–8. PMID 11134363.
- Uusitalo H, Hiltunen A, Söderström M, et al. (2001). "Expression of cathepsins B, H, K, L, and S and matrix metalloproteinases 9 and 13 during chondrocyte hypertrophy and endochondral ossification in mouse fracture callus. ". Calcif. Tissue Int. 67 (5): 382–90. PMID 11136537.
- Pol E, Björk I (2001). "Role of the single cysteine residue, Cys 3, of human and bovine cystatin B (stefin B) in the inhibition of cysteine proteinases. ". Protein Sci. 10 (9): 1729–38. PMID 11514663.
- Waghray A, Keppler D, Sloane BF, et al. (2002). "Analysis of a truncated form of cathepsin H in human prostate tumor cells. ". J. Biol. Chem. 277 (13): 11533–8. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11796715.
- Brasch F, Ten Brinke A, Johnen G, et al. (2002). "Involvement of cathepsin H in the processing of the hydrophobic surfactant-associated protein C in type II pneumocytes. ". Am. J. Respir. Cell Mol. Biol. 26 (6): 659–70. PMID 12034564.
- Bühling F, Waldburg N, Krüger S, et al. (2003). "Expression of cathepsins B, H, K, L, and S during human fetal lung development. ". Dev. Dyn. 225 (1): 14–21. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12203716.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ". Proc. Natl. Acad. Sci. U. S. A. 99 (26): 16899–903. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12477932.
- Jenko S, Dolenc I, Guncar G, et al. (2003). "Crystal structure of Stefin A in complex with cathepsin H: N-terminal residues of inhibitors can adapt to the active sites of endo- and exopeptidases. ". J. Mol. Biol. 326 (3): 875–85. PMID 12581647.
- Nagai A, Terashima M, Harada T, et al. (2003). "Cathepsin B and H activities and cystatin C concentrations in cerebrospinal fluid from patients with leptomeningeal metastasis. ". Clin. Chim. Acta 329 (1-2): 53–60. PMID 12589965.
- Han SR, Momeni A, Strach K, et al. (2004). "Enzymatically modified LDL induces cathepsin H in human monocytes: potential relevance in early atherogenesis. ". Arterioscler. Thromb. Vasc. Biol. 23 (4): 661–7. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12615673.
- Dodt J, Reichwein J (2004). "Human cathepsin H: deletion of the mini-chain switches substrate specificity from aminopeptidase to endopeptidase. ". Biol. Chem. 384 (9): 1327–32. PMID 14515996.
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