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Crystallin, zeta (quinone reductase)
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| PDB rendering based on 1yb5. The Protein Data Bank ( PDB) is a repository for 3-D structural data of Proteins and Nucleic acids These data typically obtained by X-ray crystallography | ||
| Available structures: 1yb5 | ||
| Identifiers | ||
| Symbol(s) | CRYZ; DKFZp779E0834; FLJ41475 | |
| External IDs | OMIM: 123691 MGI: 88527 HomoloGene: 68210 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 1429 | 12972 |
| Ensembl | ENSG00000116791 | ENSMUSG00000028199 |
| Uniprot | Q08257 | Q3UYY0 |
| Refseq | NM_001889 (mRNA) NP_001880 (protein) |
NM_009968 (mRNA) NP_034098 (protein) |
| Location | Chr 1: 74.94 - 74.97 Mb | Chr 3: 154.53 - 154.56 Mb |
| Pubmed search | [1] | [2] |
Crystallin, zeta (quinone reductase), also known as CRYZ, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. The former class is also called phylogenetically-restricted crystallins. This gene encodes a taxon-specific crystallin protein which has NADPH-dependent quinone reductase activity distinct from other known quinone reductases. It lacks alcohol dehydrogenase activity although by similarity it is considered a member of the zinc-containing alcohol dehydrogenase family. Unlike other mammalian species, in humans, lens expression is low. One pseudogene is known to exist. [1]
References
Further reading
- Heinzmann C, Kojis TL, Gonzalez P, et al. (1995). "Assignment of the zeta-crystallin gene (CRYZ) to human chromosome 1p22-p31 and identification of restriction fragment length polymorphisms. ". Genomics 23 (2): 403-7. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 7835889.
- Gonzalez P, Rao PV, Zigler JS (1994). "Organization of the human zeta-crystallin/quinone reductase gene (CRYZ). ". Genomics 21 (2): 317-24. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 8088825.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. ". Gene 138 (1-2): 171-4. PMID 8125298.
- Gonzalez P, Rao PV, Zigler JS (1993). "Molecular cloning and sequencing of zeta-crystallin/quinone reductase cDNA from human liver. ". Biochem. Biophys. Res. Commun. 191 (3): 902-7. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 8466529.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. ". Gene 200 (1-2): 149-56. PMID 9373149.
- Wang W, Liu LQ, Higuchi CM, Chen H (1998). "Induction of NADPH:quinone reductase by dietary phytoestrogens in colonic Colo205 cells. ". Biochem. Pharmacol. 56 (2): 189-95. PMID 9698072.
- Goenka S, Raman B, Ramakrishna T, Rao CM (2001). "Unfolding and refolding of a quinone oxidoreductase: alpha-crystallin, a molecular chaperone, assists its reactivation. ". Biochem. J. 359 (Pt 3): 547-56. PMID 11672428.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ". Proc. Natl. Acad. Sci. U. S. A. 99 (26): 16899-903. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12477932.
- Bianco NR, Perry G, Smith MA, et al. (2004). "Functional implications of antiestrogen induction of quinone reductase: inhibition of estrogen-induced deoxyribonucleic acid damage. ". Mol. Endocrinol. 17 (7): 1344-55. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12714703.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs. ". Nat. Genet. 36 (1): 40-5. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ". Genome Res. 14 (10B): 2121-7. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15489334.
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