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CREB regulated transcription coactivator 2
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| Identifiers | ||
| Symbol(s) | CRTC2; RP11-422P24. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome 6; TORC2 | |
| External IDs | OMIM: 608972 MGI: 1921593 HomoloGene: 18765 | |
| Orthologs | ||
| Human | Mouse | |
| Entrez | 200186 | 74343 |
| Ensembl | ENSG00000160741 | ENSMUSG00000027936 |
| Refseq | NM_181715 (mRNA) NP_859066 (protein) |
NM_028881 (mRNA) NP_083157 (protein) |
| Location | Chr 1: 152.19 - 152.2 Mb | Chr 3: 90.34 - 90.35 Mb |
| Pubmed search | [1] | [2] |
CREB regulated transcription coactivator 2, also known as CRTC2, is a human gene. The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
References
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. ". Gene 138 (1-2): 171-4. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. ". Gene 200 (1-2): 149-56. PMID 9373149.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ". Proc. Natl. Acad. Sci. U. S. A. 99 (26): 16899-903. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12477932.
- Iourgenko V, Zhang W, Mickanin C, et al. (2003). "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. ". Proc. Natl. Acad. Sci. U. S. A. 100 (21): 12147-52. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 14506290.
- Conkright MD, Canettieri G, Screaton R, et al. (2003). "TORCs: transducers of regulated CREB activity. ". Mol. Cell 12 (2): 413-23. PMID 14536081.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs. ". Nat. Genet. 36 (1): 40-5. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 14702039.
- Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. ". Curr. Biol. 14 (16): 1436-50. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15324660.
- Screaton RA, Conkright MD, Katoh Y, et al. (2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. ". Cell 119 (1): 61-74. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15454081.
- Al-Hakim AK, Göransson O, Deak M, et al. (2006). "14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK. ". J. Cell. Sci. 118 (Pt 23): 5661-73. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16306228.
- Siu YT, Chin KT, Siu KL, et al. (2006). "TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats. ". J. Virol. 80 (14): 7052-9. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16809310.
- Wu Z, Huang X, Feng Y, et al. (2006). "Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells. ". Proc. Natl. Acad. Sci. U. S. A. 103 (39): 14379-84. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16980408.
- Yang Q, Inoki K, Ikenoue T, Guan KL (2006). "Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity. ". Genes Dev. 20 (20): 2820-32. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 17043309.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry. ". Mol. Syst. Biol. 3: 89. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 17353931.
- Ravnskjaer K, Kester H, Liu Y, et al. (2007). "Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression. ". EMBO J. 26 (12): 2880-9. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 17476304.
- Kuraishy AI, French SW, Sherman M, et al. (2007). "TORC2 regulates germinal center repression of the TCL1 oncoprotein to promote B cell development and inhibit transformation. ". Proc. Natl. Acad. Sci. U. S. A. 104 (24): 10175-80. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 17548807.
External links
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