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Coactosin-like 1 (Dictyostelium)
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| PDB rendering based on 1t2l. The Protein Data Bank ( PDB) is a repository for 3-D structural data of Proteins and Nucleic acids These data typically obtained by X-ray crystallography | ||
| Available structures: 1t2l, 1t3x, 1t3y, 1tmw, 1udm, 1vfq, 1wm4, 1wnj | ||
| Identifiers | ||
| Symbol(s) | COTL1; CLP; FLJ43657; MGC19733 | |
| External IDs | OMIM: 606748 MGI: 1919292 HomoloGene: 10898 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 23406 | 72042 |
| Ensembl | ENSG00000103187 | ENSMUSG00000031827 |
| Uniprot | Q14019 | Q544F6 |
| Refseq | NM_021149 (mRNA) NP_066972 (protein) |
NM_028071 (mRNA) NP_082347 (protein) |
| Location | Chr 16: 83.16 - 83.21 Mb | Chr 8: 122.7 - 122.73 Mb |
| Pubmed search | [1] | [2] |
Coactosin-like 1 (Dictyostelium), also known as COTL1, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes. [1]
References
Further reading
- Wu C, Friedlander P, Lamoureux C, et al. (1993). "cDNA clones contain autonomous replication activity. ". Biochim. Biophys. Acta 1174 (3): 241–57. PMID 7690594.
- Chen KS, Manian P, Koeuth T, et al. (1997). "Homologous recombination of a flanking repeat gene cluster is a mechanism for a common contiguous gene deletion syndrome. ". Nat. Genet. 17 (2): 154–63. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 9326934.
- Provost P, Samuelsson B, Rådmark O (1999). "Interaction of 5-lipoxygenase with cellular proteins. ". Proc. Natl. Acad. Sci. U. S. A. 96 (5): 1881–5. PMID 10051563.
- Provost P, Doucet J, Hammarberg T, et al. (2001). "5-Lipoxygenase interacts with coactosin-like protein. ". J. Biol. Chem. 276 (19): 16520–7. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11297527.
- Provost P, Doucet J, Stock A, et al. (2001). "Coactosin-like protein, a human F-actin-binding protein: critical role of lysine-75. ". Biochem. J. 359 (Pt 2): 255–63. PMID 11583571.
- Nakatsura T, Senju S, Ito M, et al. (2002). "Cellular and humoral immune responses to a human pancreatic cancer antigen, coactosin-like protein, originally defined by the SEREX method. ". Eur. J. Immunol. 32 (3): 826–36. PMID 11870627.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ". Proc. Natl. Acad. Sci. U. S. A. 99 (26): 16899–903. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12477932.
- Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. ". Nat. Biotechnol. 21 (5): 566–9. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12665801.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs. ". Nat. Genet. 36 (1): 40–5. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 14702039.
- Dai H, Wu J, Xu Y, et al. (2005). "1H, 13C and 15N resonance assignments and the secondary structures of human coactosin like protein (hCLP) D123N. ". J. Biomol. NMR 29 (3): 455–6. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15213466.
- Liu L, Wang Y, Zhang P, et al. (2005). "Expression, purification and preliminary crystallographic studies of human coactosin-like protein. ". Acta Crystallogr. D Biol. Crystallogr. 60 (Pt 9): 1651–3. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15333945.
- Li X, Liu X, Lou Z, et al. (2005). "Crystal structure of human coactosin-like protein at 1. 9 A resolution. ". Protein Sci. 13 (11): 2845–51. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15459340.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ". Genome Res. 14 (10B): 2121–7. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15489334.
- Li X, Liu X, Zhao Q, et al. (2005). "Crystallization and preliminary crystallographic studies of human coactosin-like protein (CLP). ". Acta Crystallogr. D Biol. Crystallogr. 60 (Pt 12 Pt 2): 2387–8. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15583396.
- Gevaert K, Staes A, Van Damme J, et al. (2006). "Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC. ". Proteomics 5 (14): 3589–99. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16097034.
- Rakonjac M, Fischer L, Provost P, et al. (2006). "Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production. ". Proc. Natl. Acad. Sci. U. S. A. 103 (35): 13150–5. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16924104.
- Dai H, Huang W, Xu J, et al. (2006). "Binding model of human coactosin-like protein with filament actin revealed by mutagenesis. ". Biochim. Biophys. Acta 1764 (11): 1688–700. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 17070122.
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