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C-type lectin domain family 1, member A
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| Identifiers | ||
| Symbol(s) | CLEC1A; CLEC1; MGC34328 | |
| External IDs | OMIM: 606782 MGI: 2444151 HomoloGene: 9549 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 51267 | 243653 |
| Ensembl | ENSG00000150048 | ENSMUSG00000033082 |
| Uniprot | Q8NC01 | Q8BWY2 |
| Refseq | NM_016511 (mRNA) NP_057595 (protein) |
NM_175526 (mRNA) NP_780735 (protein) |
| Location | Chr 12: 10.11 - 10.14 Mb | Chr 6: 129.39 - 129.42 Mb |
| Pubmed search | [1] | [2] |
C-type lectin domain family 1, member A, also known as CLEC1A, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded protein may play a role in regulating dendritic cell function. Alternative splice variants have been described but their biological nature has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [1]
References
Further reading
- Drickamer K (1999). "C-type lectin-like domains. ". Curr. Opin. Struct. Biol. 9 (5): 585–90. PMID 10508765.
- Colonna M, Samaridis J, Angman L (2000). "Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells. ". Eur. J. Immunol. 30 (2): 697–704. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 10671229.
- Sobanov Y, Bernreiter A, Derdak S, et al. (2002). "A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex. ". Eur. J. Immunol. 31 (12): 3493–503. PMID 11745369.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ". Proc. Natl. Acad. Sci. U. S. A. 99 (26): 16899–903. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12477932.
- Ebner S, Sharon N, Ben-Tal N (2003). "Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily. ". Proteins 53 (1): 44–55. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12945048.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. ". Genome Res. 13 (10): 2265–70. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12975309.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs. ". Nat. Genet. 36 (1): 40–5. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ". Genome Res. 14 (10B): 2121–7. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15489334.
- Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. ". DNA Res. 12 (2): 117–26. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16303743.
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