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Carboxylesterase 3 (brain)
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| Identifiers | ||
| Symbol(s) | CES3; Br3; ES31; FLJ21736 | |
| External IDs | OMIM: 605279 | |
| Orthologs | ||
| Human | Mouse | |
| Entrez | 23491 | n/a
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| Refseq | NM_024922 (mRNA) NP_079198 (protein) |
n/a (mRNA) n/a (protein) |
| Pubmed search | [1] | n/a |
Carboxylesterase 3 (brain), also known as CES3, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
Carboxylesterase 3 is a member of a large multigene family. The enzymes encoded by these genes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolize long-chain fatty acid esters and thioesters. The specific function of this enzyme has not yet been determined; however, it is speculated that carboxylesterases may play a role in lipid metabolism and/or the blood-brain barrier system. [1]
References
Further reading
- Lee CV, Hymowitz SG, Wallweber HJ, et al. (2006). "Synthetic anti-BR3 antibodies that mimic BAFF binding and target both human and murine B cells. ". Blood 108 (9): 3103-11. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16840730.
- Hassel S, Eichner A, Yakymovych M, et al. (2004). "Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry. ". Proteomics 4 (5): 1346-58. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15188402.
- Sanghani SP, Quinney SK, Fredenburg TB, et al. (2004). "Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin, by human carboxylesterases CES1A1, CES2, and a newly expressed carboxylesterase isoenzyme, CES3. ". Drug Metab. Dispos. 32 (5): 505-11. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15100172.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs. ". Nat. Genet. 36 (1): 40-5. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 14702039.
- Sanghani SP, Quinney SK, Fredenburg TB, et al. (2004). "Carboxylesterases expressed in human colon tumor tissue and their role in CPT-11 hydrolysis. ". Clin. Cancer Res. 9 (13): 4983-91. PMID 14581373.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. ". Genome Res. 13 (10): 2265-70. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12975309.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ". Proc. Natl. Acad. Sci. U. S. A. 99 (26): 16899-903. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12477932.
- Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome. ". Science 291 (5507): 1304-51. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11181995.
- Mori M, Hosokawa M, Ogasawara Y, et al. (1999). "cDNA cloning, characterization and stable expression of novel human brain carboxylesterase. ". FEBS Lett. 458 (1): 17-22. PMID 10518925.
- Aida K, Moore R, Negishi M (1993). "Cloning and nucleotide sequence of a novel, male-predominant carboxylesterase in mouse liver. ". Biochim. Biophys. Acta 1174 (1): 72-4. PMID 7916639.
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