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Cell division cycle 20 homolog (S. cerevisiae)
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| Identifiers | ||
| Symbol(s) | CDC20; CDC20A; MGC102824; bA276H19. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome 3; p55CDC | |
| External IDs | OMIM: 603618 MGI: 1859866 HomoloGene: 37459 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 991 | 107995 |
| Ensembl | ENSG00000117399 | ENSMUSG00000006398 |
| Uniprot | Q12834 | Q9JJ66 |
| Refseq | NM_001255 (mRNA) NP_001246 (protein) |
NM_023223 (mRNA) NP_075712 (protein) |
| Location | Chr 1: 43.6 - 43.6 Mb | Chr 4: 117.93 - 117.94 Mb |
| Pubmed search | [1] | [2] |
Cell division cycle 20 homolog (S. The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles cerevisiae), also known as CDC20, is a human gene. History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance
CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separation. [1]
References
Further reading
- Weinstein J, Jacobsen FW, Hsu-Chen J, et al. (1994). "A novel mammalian protein, p55CDC, present in dividing cells is associated with protein kinase activity and has homology to the Saccharomyces cerevisiae cell division cycle proteins Cdc20 and Cdc4. ". Mol. Cell. Biol. 14 (5): 3350–63. PMID 7513050.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. ". Gene 138 (1-2): 171–4. PMID 8125298.
- Weinstein J (1997). "Cell cycle-regulated expression, phosphorylation, and degradation of p55Cdc. A mammalian homolog of CDC20/Fizzy/slp1. ". J. Biol. Chem. 272 (45): 28501–11. PMID 9353311.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. ". Gene 200 (1-2): 149–56. PMID 9373149.
- Kallio M, Weinstein J, Daum JR, et al. (1998). "Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events. ". J. Cell Biol. 141 (6): 1393–406. PMID 9628895.
- Fang G, Yu H, Kirschner MW (1998). "The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation. ". Genes Dev. 12 (12): 1871–83. PMID 9637688.
- Weinstein J, Karim J, Geschwind DH, et al. (1998). "Genomic organization, 5' flanking enhancer region, and chromosomal assignment of the cell cycle gene, p55Cdc. ". Mol. Genet. Metab. 64 (1): 52–7. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 9682218.
- Fang G, Yu H, Kirschner MW (1998). "Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1. ". Mol. Cell 2 (2): 163–71. PMID 9734353.
- Wassmann K, Benezra R (1998). "Mad2 transiently associates with an APC/p55Cdc complex during mitosis. ". Proc. Natl. Acad. Sci. U. S. A. 95 (19): 11193–8. PMID 9736712.
- Kramer ER, Gieffers C, Hölzl G, et al. (1999). "Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family. ". Curr. Biol. 8 (22): 1207–10. PMID 9811605.
- Cahill DP, da Costa LT, Carson-Walter EB, et al. (1999). "Characterization of MAD2B and other mitotic spindle checkpoint genes. ". Genomics 58 (2): 181–7. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 10366450.
- Farruggio DC, Townsley FM, Ruderman JV (1999). "Cdc20 associates with the kinase aurora2/Aik. ". Proc. Natl. Acad. Sci. U. S. A. 96 (13): 7306–11. PMID 10377410.
- Kotani S, Tanaka H, Yasuda H, Todokoro K (1999). "Regulation of APC activity by phosphorylation and regulatory factors. ". J. Cell Biol. 146 (4): 791–800. PMID 10459014.
- Ohtoshi A, Maeda T, Higashi H, et al. (2000). "Human p55(CDC)/Cdc20 associates with cyclin A and is phosphorylated by the cyclin A-Cdk2 complex. ". Biochem. Biophys. Res. Commun. 268 (2): 530–4. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 10679238.
- Luo X, Fang G, Coldiron M, et al. (2000). "Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20. ". Nat. Struct. Biol. 7 (3): 224–9. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 10700282.
- Wu H, Lan Z, Li W, et al. (2000). "p55CDC/hCDC20 is associated with BUBR1 and may be a downstream target of the spindle checkpoint kinase. ". Oncogene 19 (40): 4557–62. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11030144.
- Skoufias DA, Andreassen PR, Lacroix FB, et al. (2001). "Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints. ". Proc. Natl. Acad. Sci. U. S. A. 98 (8): 4492–7. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11274370.
- Reimann JD, Freed E, Hsu JY, et al. (2001). "Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. ". Cell 105 (5): 645–55. PMID 11389834.
- Zhang Y, Lees E (2001). "Identification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex: model for spindle checkpoint regulation. ". Mol. Cell. Biol. 21 (15): 5190–9. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11438673.
- Chen J, Fang G (2001). "MAD2B is an inhibitor of the anaphase-promoting complex. ". Genes Dev. 15 (14): 1765–70. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11459826.
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