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CD48 molecule
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| Identifiers | ||
| Symbol(s) | CD48; BCM1; BLAST; BLAST1; MEM-102; SLAMF2; hCD48; mCD48 | |
| External IDs | OMIM: 109530 MGI: 88339 HomoloGene: 1347 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 962 | 12506 |
| Ensembl | ENSG00000117091 | ENSMUSG00000015355 |
| Uniprot | P09326 | Q9R1N8 |
| Refseq | NM_001778 (mRNA) NP_001769 (protein) |
NM_007649 (mRNA) NP_031675 (protein) |
| Location | Chr 1: 158.92 - 158.95 Mb | Chr 1: 173.52 - 173.54 Mb |
| Pubmed search | [1] | [2] |
CD48 (Cluster of Differentiation 48) is a human protein encoded by the CD48 gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles Proteins are large Organic compounds made of Amino acids arranged in a linear chain and joined together by Peptide bonds between the Carboxyl History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
Contents |
See also
References
- ^ Entrez Gene: CD48 CD48 molecule. The cluster of differentiation (often abbreviated as CD) is a protocol used for the identification and investigation of Cell surface molecules present on Leukocytes
Further reading
- Shin JS, Abraham SN (2001). "Glycosylphosphatidylinositol-anchored receptor-mediated bacterial endocytosis. ". FEMS Microbiol. Lett. 197 (2): 131–8. PMID 11313125.
- Wong YW, Williams AF, Kingsmore SF, Seldin MF (1990). "Structure, expression, and genetic linkage of the mouse BCM1 (OX45 or Blast-1) antigen. Evidence for genetic duplication giving rise to the BCM1 region on mouse chromosome 1 and the CD2/LFA3 region on mouse chromosome 3. ". J. Exp. Med. 171 (6): 2115–30. PMID 1693656.
- Del Porto P, Mami-Chouaib F, Bruneau JM, et al. (1991). "TCT. 1, a target molecule for gamma/delta T cells, is encoded by an immunoglobulin superfamily gene (Blast-1) located in the CD1 region of human chromosome 1. ". J. Exp. Med. 173 (6): 1339–44. PMID 1827826.
- Fisher RC, Thorley-Lawson DA (1991). "Characterization of the Epstein-Barr virus-inducible gene encoding the human leukocyte adhesion and activation antigen BLAST-1 (CD48). ". Mol. Cell. Biol. 11 (3): 1614–23. PMID 1847502.
- Korínek V, Stefanová I, Angelisová P, et al. (1991). "The human leucocyte antigen CD48 (MEM-102) is closely related to the activation marker Blast-1. ". Immunogenetics 33 (2): 108–12. PMID 1999350.
- Vaughan HA, Henning MM, Purcell DF, et al. (1991). "The isolation of cDNA clones for CD48. ". Immunogenetics 33 (2): 113–7. PMID 1999351.
- Staunton DE, Thorley-Lawson DA (1988). "Molecular cloning of the lymphocyte activation marker Blast-1. ". EMBO J. 6 (12): 3695–701. PMID 2828034.
- Garnett D, Barclay AN, Carmo AM, Beyers AD (1993). "The association of the protein tyrosine kinases p56lck and p60fyn with the glycosyl phosphatidylinositol-anchored proteins Thy-1 and CD48 in rat thymocytes is dependent on the state of cellular activation. ". Eur. J. Immunol. 23 (10): 2540–4. PMID 8104794.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. ". Gene 138 (1-2): 171–4. PMID 8125298.
- Solomon KR, Rudd CE, Finberg RW (1996). "The association between glycosylphosphatidylinositol-anchored proteins and heterotrimeric G protein alpha subunits in lymphocytes. ". Proc. Natl. Acad. Sci. U. S. A. 93 (12): 6053–8. PMID 8650218.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. ". Gene 200 (1-2): 149–56. PMID 9373149.
- Smith GM, Biggs J, Norris B, et al. (1998). "Detection of a soluble form of the leukocyte surface antigen CD48 in plasma and its elevation in patients with lymphoid leukemias and arthritis. ". J. Clin. Immunol. 17 (6): 502–9. PMID 9418191.
- Latchman Y, McKay PF, Reiser H (1998). "Identification of the 2B4 molecule as a counter-receptor for CD48. ". J. Immunol. 161 (11): 5809–12. PMID 9834056.
- Nakajima H, Cella M, Langen H, et al. (1999). "Activating interactions in human NK cell recognition: the role of 2B4-CD48. ". Eur. J. Immunol. 29 (5): 1676–83. PMID 10359122.
- Tangye SG, Cherwinski H, Lanier LL, Phillips JH (2001). "2B4-mediated activation of human natural killer cells. ". Mol. Immunol. 37 (9): 493–501. PMID 11163399.
- Suzuki T, Kiyokawa N, Taguchi T, et al. (2001). "CD24 induces apoptosis in human B cells via the glycolipid-enriched membrane domains/rafts-mediated signaling system. ". J. Immunol. 166 (9): 5567–77. PMID 11313396.
- Hawash IY, Hu XE, Adal A, et al. (2002). "The oxygen-substituted palmitic acid analogue, 13-oxypalmitic acid, inhibits Lck localization to lipid rafts and T cell signaling. ". Biochim. Biophys. Acta 1589 (2): 140–50. PMID 12007789.
- Kim D, Hur DY, Kim YS, et al. (2002). "CM1 ligation initiates apoptosis in a caspase 8-dependent manner in Ramos cells and in a mitochondria-controlled manner in Raji cells. ". Hum. Immunol. 63 (7): 576–87. PMID 12072193.
- Zhu B, Davies EA, van der Merwe PA, et al. (2002). "Direct measurements of heterotypic adhesion between the cell surface proteins CD2 and CD48. ". Biochemistry 41 (40): 12163–70. PMID 12356317.
External links
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