CD3D - Citizendia

CD3d molecule, delta (CD3-TCR complex)

PDB rendering based on 1xiw. The Protein Data Bank ( PDB) is a repository for 3-D structural data of Proteins and Nucleic acids These data typically obtained by X-ray crystallography
Available structures: 1xiw
Identifiers
Symbol(s)	CD3D; CD3-DELTA; T3D
External IDs	OMIM: 186790 MGI: 88331 HomoloGene: 585

RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	915	12500
Ensembl	ENSG00000167286	ENSMUSG00000032094
Uniprot	P04234	A0N8K9
Refseq	NM_000732 (mRNA) NP_000723 (protein)	NM_013487 (mRNA) NP_038515 (protein)
Location	Chr 11: 117.72 - 117.72 Mb	Chr 9: 44.73 - 44.74 Mb
Pubmed search	[1]	[2]

CD3d molecule, delta (CD3-TCR complex), also known as CD3D, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance ^[1]

References

^ Entrez Gene: CD3D CD3d molecule, delta (CD3-TCR complex). In Immunology, the CD3 Antigen (CD stands for Cluster of differentiation) is a protein complex and is composed of four distinct chains The cluster of differentiation (often abbreviated as CD) is a protocol used for the identification and investigation of Cell surface molecules present on Leukocytes

Balk SP, Polischuk JE, Probert C, et al. (1996). "Composition of TCR-CD3 complex in human intestinal intraepithelial lymphocytes: lack of Fc epsilon RI gamma chain. ". Int. Immunol. 7 (8): 1237-41. PMID 7495730.
Li CJ (2007). "Therapeutic biology: checkpoint pathway activation therapy, HIV Tat, and transkingdom RNA interference. ". J. Cell. Physiol. 209 (3): 695-700. doi:10.1002/jcp.20817. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 17001685.
Phillips JH, Hori T, Nagler A, et al. (1992). "Ontogeny of human natural killer (NK) cells: fetal NK cells mediate cytolytic function and express cytoplasmic CD3 epsilon,delta proteins. ". J. Exp. Med. 175 (4): 1055-66. PMID 1372642.
Luzzati AL, Giacomini E, Giordani L, et al. (1992). "The antigen-specific induction of normal human lymphocytes in vitro is down-regulated by a conserved HIV p24 epitope. ". Immunol. Lett. 33 (3): 307-14. PMID 1385321.
Alarcón B, Ley SC, Sánchez-Madrid F, et al. (1991). "The CD3-gamma and CD3-delta subunits of the T cell antigen receptor can be expressed within distinct functional TCR/CD3 complexes. ". EMBO J. 10 (4): 903-12. PMID 1826255.
Hori T, de Waal Malefyt R, Duncan BW, et al. (1991). "Cloning of a novel cell type from human fetal liver expressing cytoplasmic CD3 delta and epsilon but not membrane CD3. ". Int. Immunol. 3 (4): 353-7. PMID 1831653.
Ruegg CL, Strand M (1991). "A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx. ". Cell. Immunol. 137 (1): 1-13. PMID 1832084.
Cefai D, Debre P, Kaczorek M, et al. (1991). "Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway. ". J. Clin. Invest. 86 (6): 2117-24. PMID 1979339.
Luzzati AL, Pugliese O, Giacomini E, et al. (1990). "Immunoregulatory effect of a synthetic peptide corresponding to a region of protein p24 of HIV. ". Folia Biol. (Praha) 36 (1): 71-7. PMID 2111780.
Koning F, Maloy WL, Coligan JE (1990). "The implications of subunit interactions for the structure of the T cell receptor-CD3 complex. ". Eur. J. Immunol. 20 (2): 299-305. PMID 2138083.
Alexander D, Goris J, Marais R, et al. (1989). "Dephosphorylation of the human T lymphocyte CD3 antigen. ". Eur. J. Biochem. 181 (1): 55-65. PMID 2540970.
Tunnacliffe A, Buluwela L, Rabbitts TH (1988). "Physical linkage of three CD3 genes on human chromosome 11. ". EMBO J. 6 (10): 2953-7. PMID 2826124.
van den Elsen P, Shepley BA, Cho M, Terhorst C (1985). "Isolation and characterization of a cDNA clone encoding the murine homologue of the human 20K T3/T-cell receptor glycoprotein. ". Nature 314 (6011): 542-4. PMID 2859526.
van den Elsen P, Georgopoulos K, Shepley BA, et al. (1986). "Exon/intron organization of the genes coding for the delta chains of the human and murine T-cell receptor/T3 complex. ". Proc. Natl. Acad. Sci. U. S. A. 83 (9): 2944-8. PMID 2939461.
Gold DP, Clevers H, Alarcon B, et al. (1987). "Evolutionary relationship between the T3 chains of the T-cell receptor complex and the immunoglobulin supergene family. ". Proc. Natl. Acad. Sci. U. S. A. 84 (21): 7649-53. PMID 3478717.
Tunnacliffe A, Sims JE, Rabbitts TH (1986). "T3 delta pre-mRNA is transcribed from a non-TATA promoter and is alternatively spliced in human T cells. ". EMBO J. 5 (6): 1245-52. PMID 3488209.
van den Elsen P, Shepley BA, Borst J, et al. (1985). "Isolation of cDNA clones encoding the 20K T3 glycoprotein of human T-cell receptor complex. ". Nature 312 (5993): 413-8. PMID 6095101.
Oravecz T, Norcross MA (1994). "Costimulatory properties of the human CD4 molecule: enhancement of CD3-induced T cell activation by human immunodeficiency virus type 1 through viral envelope glycoprotein gp120. ". AIDS Res. Hum. Retroviruses 9 (10): 945-55. PMID 7506554.
Luzzati AL, Giacomini E, Giordani L, et al. (1994). "An HIV p24 heptapeptide down-regulates antigen-specific responses in vitro interfering at the level of the T3-Ti complex. ". Cell. Immunol. 156 (2): 286-95. doi:10.1006/cimm.1994.1175. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 7517794.

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See also

References

Further reading