|
chemokine (C-C motif) ligand 16
|
|
| Identifiers | |
| Symbol | CCL16 |
| Alt. Symbols | SCYA16, NCC-4, SCYL4, LEC, HCC-4, LMC, LCC-1, CKb12, Mtn-1 |
| Entrez | 6360 |
| HUGO | 10614 |
| OMIM | 601394 |
| RefSeq | NM_004590 |
| UniProt | O15467 |
| Other data | |
| Locus | Chr. 17 q11.2 |
Chemokine (C-C motif) ligand 16 (CCL16) is a small cytokine belonging to the CC chemokine family that is known under several pseudonyms, including Liver-expressed chemokine (LEC) and Monotactin-1 (MTN-1). The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mendelian Inheritance in Man project is a Database that catalogues all the known Diseases with a genetic component, and—when possible—links them The National Center for Biotechnology Information ( NCBI) is part of the United States National Library of Medicine (NLM a branch of the National Institutes Swiss-Prot is a manually curated Biological database of Protein sequences In the fields of Genetics and Evolutionary computation, a locus (plural loci) is a fixed position on a Chromosome such as the position of a Chromosome 17 is one of the 23 pairs of Chromosomes in Humans People normally have two copies of this chromosome Cytokines are a category of signalling Proteins and Glycoproteins that like Hormones and Neurotransmitters, are used extensively in cellular Chemokines are a family of small Cytokines, or Proteins secreted by cells Proteins are classified as chemokines according to shared structural characteristics A pseudonym is a fictitious alternative to a person's legal name (see Alias) This chemokine is expressed by the liver, thymus and spleen and is chemoattractive for monocytes and lymphocytes. The liver is a vital organ in the human body and is present in Vertebrates and some other animals In Human anatomy, the thymus is an organ located in the upper Anterior portion of the chest cavity just behind the Sternum. The spleen is an organ found in all Vertebrate animals In humans the spleen is located in the abdomen of the body where it functions in the destruction of redundant Red Monocyte is a type of Leukocyte, part of the Human body 's Immune system. A lymphocyte is a type of White blood cell in the Vertebrate Immune system. [1] Cellular expression of CCL16 can be strongly induced in monocytes by IL-10, IFN-γ and bacterial lipopolysaccharide. Interferons ( IFN s are natural Proteins produced by the cells of the Immune system of most Vertebrates in response to challenges by foreign agents Lipopolysaccharides ( LPS) are large Molecules consisting of a Lipid and a Polysaccharide joined by a Covalent bond; they are found Its gene is located on chromosome 17, in humans, among a cluster of other CC chemokines. History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance Chromosome 17 is one of the 23 pairs of Chromosomes in Humans People normally have two copies of this chromosome [2] CCL16 elicits its effects on cells by interacting with cell surface chemokine receptors such as CCR1, CCR2, CCR5 and CCR8. CC chemokine receptors are Integral membrane proteins that specifically bind and respond to Cytokines of the CC chemokine CC chemokine receptors are Integral membrane proteins that specifically bind and respond to Cytokines of the CC chemokine CC chemokine receptors are Integral membrane proteins that specifically bind and respond to Cytokines of the CC chemokine CC chemokine receptors are Integral membrane proteins that specifically bind and respond to Cytokines of the CC chemokine [3][4]
References
- ^ Youn et al. Isolation and characterization of LMC, a novel lymphocyte and monocyte chemoattractant human CC chemokine, with myelosuppressive activity. Biochem. Biophys. Res. Commun. 247:217-222 (1998).
- ^ Nomiyama et al. Organization of the chemokine gene cluster on human chromosome 17q11. 2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES. J. Interferon Cytokine Res. 19:227-234 (1999).
- ^ Nomiyama et al. Human CC chemokine liver-expressed chemokine/CCL16 is a functional ligand for CCR1, CCR2 and CCR5, and constitutively expressed by hepatocytes. Int Immunol. 2001 Aug;13(8):1021-9.
- ^ Howard et al. LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8. Blood. 2000 Aug 1;96(3):840-5.
Dapyx Software network: MP3 Explorer | Ebook Manager | Zenithic