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Calcium channel, voltage-dependent, beta 2 subunit
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| PDB rendering based on 1t0h. The Protein Data Bank ( PDB) is a repository for 3-D structural data of Proteins and Nucleic acids These data typically obtained by X-ray crystallography | ||
| Available structures: 1t0h, 1t0j | ||
| Identifiers | ||
| Symbol(s) | CACNB2; CACNLB2; FLJ23743; MYSB | |
| External IDs | OMIM: 600003 MGI: 894644 HomoloGene: 75191 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 783 | 12296 |
| Ensembl | ENSG00000165995 | ENSMUSG00000057914 |
| Uniprot | Q08289 | Q32MF3 |
| Refseq | NM_000724 (mRNA) NP_000715 (protein) |
NM_023116 (mRNA) NP_075605 (protein) |
| Location | Chr 10: 18.47 - 18.87 Mb | Chr 2: 14.52 - 14.9 Mb |
| Pubmed search | [1] | [2] |
Calcium channel, voltage-dependent, beta 2 subunit, also known as CACNB2, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
Contents |
See also
References
- ^ Entrez Gene: CACNB2 calcium channel, voltage-dependent, beta 2 subunit. Voltage-dependent calcium channels (VDCC are a group of voltage-gated Ion channels found in excitable cells ( e
Further reading
- Williams ME, Feldman DH, McCue AF, et al. (1992). "Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype. ". Neuron 8 (1): 71–84. PMID 1309651.
- Brust PF, Simerson S, McCue AF, et al. (1994). "Human neuronal voltage-dependent calcium channels: studies on subunit structure and role in channel assembly. ". Neuropharmacology 32 (11): 1089–102. PMID 8107964.
- Rosenfeld MR, Wong E, Dalmau J, et al. (1993). "Cloning and characterization of a Lambert-Eaton myasthenic syndrome antigen. ". Ann. Neurol. 33 (1): 113–20. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 8494331.
- Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags. ". Genome Res. 6 (9): 807–28. PMID 8889549.
- Volsen SG, Day NC, McCormack AL, et al. (1997). "The expression of voltage-dependent calcium channel beta subunits in human cerebellum. ". Neuroscience 80 (1): 161–74. PMID 9252229.
- Taviaux S, Williams ME, Harpold MM, et al. (1997). "Assignment of human genes for beta 2 and beta 4 subunits of voltage-dependent Ca2+ channels to chromosomes 10p12 and 2q22-q23. ". Hum. Genet. 100 (2): 151–4. PMID 9254841.
- Robertson HM, Zumpano KL (1998). "Molecular evolution of an ancient mariner transposon, Hsmar1, in the human genome. ". Gene 205 (1-2): 203–17. PMID 9461395.
- Allen TJ, Mikala G (1998). "Effects of temperature on human L-type cardiac Ca2+ channels expressed in Xenopus oocytes. ". Pflugers Arch. 436 (2): 238–47. PMID 9594024.
- Day NC, Volsen SG, McCormack AL, et al. (1998). "The expression of voltage-dependent calcium channel beta subunits in human hippocampus. ". Brain Res. Mol. Brain Res. 60 (2): 259–69. PMID 9757060.
- Brice NL, Dolphin AC (1999). "Differential plasma membrane targeting of voltage-dependent calcium channel subunits expressed in a polarized epithelial cell line. ". J. Physiol. (Lond. ) 515 ( Pt 3): 685–94. PMID 10066897.
- Gerhardstein BL, Puri TS, Chien AJ, Hosey MM (1999). "Identification of the sites phosphorylated by cyclic AMP-dependent protein kinase on the beta 2 subunit of L-type voltage-dependent calcium channels. ". Biochemistry 38 (32): 10361–70. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 10441130.
- Lie AA, Blümcke I, Volsen SG, et al. (1999). "Distribution of voltage-dependent calcium channel beta subunits in the hippocampus of patients with temporal lobe epilepsy. ". Neuroscience 93 (2): 449–56. PMID 10465427.
- Bünemann M, Gerhardstein BL, Gao T, Hosey MM (1999). "Functional regulation of L-type calcium channels via protein kinase A-mediated phosphorylation of the beta(2) subunit. ". J. Biol. Chem. 274 (48): 33851–4. PMID 10567342.
- Yamaguchi H, Okuda M, Mikala G, et al. (2000). "Cloning of the beta(2a) subunit of the voltage-dependent calcium channel from human heart: cooperative effect of alpha(2)/delta and beta(2a) on the membrane expression of the alpha(1C) subunit. ". Biochem. Biophys. Res. Commun. 267 (1): 156–63. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 10623591.
- Colecraft HM, Alseikhan B, Takahashi SX, et al. (2002). "Novel functional properties of Ca(2+) channel beta subunits revealed by their expression in adult rat heart cells. ". J. Physiol. (Lond. ) 541 (Pt 2): 435–52. PMID 12042350.
- Takahashi SX, Mittman S, Colecraft HM (2004). "Distinctive modulatory effects of five human auxiliary beta2 subunit splice variants on L-type calcium channel gating. ". Biophys. J. 84 (5): 3007–21. PMID 12719232.
- Finlin BS, Crump SM, Satin J, Andres DA (2004). "Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases. ". Proc. Natl. Acad. Sci. U. S. A. 100 (24): 14469–74. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 14623965.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs. ". Nat. Genet. 36 (1): 40–5. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 14702039.
- Foell JD, Balijepalli RC, Delisle BP, et al. (2004). "Molecular heterogeneity of calcium channel beta-subunits in canine and human heart: evidence for differential subcellular localization. ". Physiol. Genomics 17 (2): 183–200. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 14762176.
- Harry JB, Kobrinsky E, Abernethy DR, Soldatov NM (2004). "New short splice variants of the human cardiac Cavbeta2 subunit: redefining the major functional motifs implemented in modulation of the Cav1. 2 channel. ". J. Biol. Chem. 279 (45): 46367–72. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15339916.
External links
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