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Budesonide
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| Systematic (IUPAC) name | |
| 16,17-(butylidenebis(oxy))-11,21-dihydroxy-, (11-β,16-α)-pregna-1,4-diene-3,20-dione | |
| Identifiers | |
| CAS number | |
| ATC code | A07 D07AC09, R01AD05, R03BA02 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C25H34O6 |
| Mol. mass | 430. IUPAC Nomenclature is a system of naming Chemical compounds and of describing the science of Chemistry in general CAS registry numbers are unique numerical identifiers for Chemical compounds Polymers biological sequences mixtures and Alloys They are also referred to The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs It is controlled by the WHO Collaborating Centre for Drug ATC code A07 is a division of the Anatomical Therapeutic Chemical Classification System and part of the A Alimentary tract and metabolism section A section of the Anatomical Therapeutic Chemical Classification System. A section of the Anatomical Therapeutic Chemical Classification System. A section of the Anatomical Therapeutic Chemical Classification System. PubChem is a Database of chemical Molecules The system is maintained by the National Center for Biotechnology Information (NCBI a component The DrugBank database available at the University of Alberta is a unique Bioinformatics and Cheminformatics resource that combines detailed drug (i A chemical formula is a way of expressing information about the Atoms that constitute a particular Chemical compound, and how the relationship between those atoms changes Carbon (kɑɹbən is a Chemical element with the symbol C and its Atomic number is 6 Hydrogen (ˈhaɪdrədʒən is the Chemical element with Atomic number 1 Oxygen (from the Greek roots ὀξύς (oxys (acid literally "sharp" from the taste of acids and -γενής (-genēs (producer literally begetteris the The molecular mass (abbreviated m of a substance, more commonly referred to as molecular weight and abbreviated as MW, is the Mass of one 534 g/mol |
| SMILES | & |
| Pharmacokinetic data | |
| Bioavailability | 100% (but large first pass effect) |
| Protein binding | 85-90% |
| Metabolism | Hepatic CYP3A4 |
| Half life | 2. In Pharmacology, bioavailability is used to describe the fraction of an administered Dose of unchanged drug that reaches the Systemic circulation, one of A drug's efficiency may be affected by the degree to which it binds to the proteins within Blood plasma. Drug metabolism is the Metabolism of drugs, their Biochemical modification or degradation usually through specialized enzymatic systems Cytochrome P450 3A4 (abbreviated CYP3A4) ( a member of the Cytochrome P450 mixed-function oxidase system is one of the most important enzymes involved in the metabolism The biological half-life of a substance is the time it takes for a substance (drug radioactive nuclide or other to lose half of its pharmacologic physiologic or radiologic activity 0-3. 6 hours |
| Excretion | Renal, Faecal |
| Therapeutic considerations | |
| Pregnancy cat. |
C(US) |
| Legal status | |
| Routes | Oral, Nasal, tracheal, rectal |
Budesonide is a glucocorticoid steroid for the treatment of asthma, non-infectious rhinitis (including hay fever and other allergies), and for treatment and prevention of nasal polyposis. Excretion is the process of eliminating waste products of Metabolism and other non-useful materials The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical if it is used as directed by the mother during The United States of America —commonly referred to as the The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction A prescription drug is a licensed medicine that is regulated by legislation to require a prescription before it can be obtained The United Kingdom of Great Britain and Northern Ireland, commonly known as the United Kingdom, the UK or Britain,is a Sovereign state located In Pharmacology and Toxicology, a route Glucocorticoids (GC are a class of Steroid hormones characterised by an ability to bind with the glucocorticoid receptor ( GR) and trigger similar effects A steroid is a Terpenoid Lipid characterized by a Carbon skeleton with four fused rings generally arranged in a 6-6-6-5 fashion Asthma is a chronic Condition involving the Respiratory system in which the airways occasionally constrict become inflamed, and are Rhinitis is the medical term describing irritation and inflammation of some internal areas of the Nose. Hay Fever is a comic play written by Noel Coward in 1924 and first produced in 1925 with Marie Tempest as the first Judith Bliss Nasal polyps are polypoidal masses arising mainly from the Mucous membranes of the Nose and Paranasal sinuses They are overgrowths of the Additionally, it is used for inflammatory bowel disease. In Medicine, inflammatory bowel disease ( IBD) is a group of inflammatory conditions of the large intestine and Small intestine It is marketed by AstraZeneca as a nasal inhalation with the brand name Rhinocort (in Denmark, as Rhinosol), as an oral inhalation with the brand name Pulmicort, and as an enema and a modified-release capsule with the brand name Entocort. AstraZeneca PLC (,) is a large Anglo-Swedish Pharmaceutical company formed on 6 April 1999 by the remerger of Swedish Astra AB It is also sold in combination with formoterol (Oxis) in a single inhaler, with the brand name Symbicort. Formoterol ( INN) or eformoterol (former BAN) is a long-acting β2-agonist used in the management of Asthma and/or Budesonide/formoterol is a combination formulation containing Budesonide and Formoterol used in the management of Asthma and Chronic obstructive pulmonary
Contents |
Pharmacology
Budesonide has a high first pass metabolism. Metabolism is the set of Chemical reactions that occur in living Organisms in order to maintain Life. It has efficacy in the terminal ileum and the right colon. In Anatomy of the Digestive system, the ileum is the final section of the Small intestine. The colon is a storage tube for solid wastes The main function of the colon appears to be extraction of Water and salts from Feces. Budesonide in comparison with prednisolone has been associated with fewer bone density losses and unlike other corticosteroids has little influence on the hypothalamic-pituitary-adrenal axis which also limit the need of tapering before discontinuation. Overall, it has a lower incidence of systemic manifestations than similar medications.
Side Effects
Budesonide may cause:
- nose irritation or burning
- bleeding or sores in the nose
- lightheadedness
- upset stomach
- cough
- hoarseness
- dry mouth
In addition the following should be reported:
- Immediately if difficulty breathing or swelling of the face
- white patches in the throat, mouth, or nose
- irregular menstrual periods
- severe acne
Recall
Pulmicort inhalers were recalled in 2002 because there was concern that they may not always have provided the full dosage.
External links
Dictionary
budesonide
-noun
- (pharmacology) A corticosteroid used in the treatment of various diseases.
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