| Bowen's disease Classification and external resources |
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| ICD-10 | D00.-D09. |
|---|---|
| ICD-9 | 230-234 |
| ICD-O: | 8081/2 |
| DiseasesDB | 1569 |
| eMedicine | derm/59 |
Bowen's disease (BD) is a neoplastic skin disease, considered either as an early stage or intraepidermal form of squamous cell carcinoma. The International Statistical Classification of Diseases and Related Health Problems (most commonly known by the abbreviation ICD) provides codes to classify Diseases The International Statistical Classification of Diseases and Related Health Problems 10th Revision ( ICD -10) is a coding of diseases and signs symptoms abnormal findings The International Statistical Classification of Diseases and Related Health Problems (most commonly known by the abbreviation ICD) provides codes to classify Diseases The following is a list of codes for International Statistical Classification of Diseases and Related Health Problems. The International Classification of Diseases for Oncology (ICD-O is a domain specific extension of the International Statistical Classification of Diseases and Related Health Problems The Diseases Database is a free Website that provides information about the relationships between medical conditions Symptoms, and Medications. eMedicine is an online clinical medical knowledge base that was founded in 1996 by Scott Plantz and Richard Lavely two medical doctors In Medicine, squamous cell carcinoma (SCC is a form of Cancer of the Carcinoma type that may occur in many different organs including the Skin It was named after Dr John T. Bowen, the doctor who first described it in 1912.
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Causes
Causes of BD include solar damage, arsenic, immunosuppression (including AIDS), viral infection (human papillomavirus or HPV) and chronic skin injury and dermatoses. Arsenic (ˈɑrsənɪk is a Chemical element that has the symbol As and Atomic number of 33 Immunosuppression involves an act that reduces the activation or Efficacy of the Immune system. A human papillomavirus ( HPV) is a Papillomavirus that infects the skin and Mucous membranes of Humans Approximately 130 HPV types have been A human papillomavirus ( HPV) is a Papillomavirus that infects the skin and Mucous membranes of Humans Approximately 130 HPV types have been
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Signs and symptoms
Bowen's disease typically presents as a gradually enlarging, well demarcated erythematous plaque with an irregular border and surface crusting or scaling. BD may occur at any age in adults but is rare before the age of 30 years - most patients are aged over 60. Any site may be affected, although involvement of palms or soles is uncommon. BD occurs predominantly in women (70-85% of cases); about three-quarters of patients have lesions on the lower leg (60-85%), usually in previously or presently sun-exposed areas of skin. A persistent progressive non-elevated red scaly or crusted plaque which is due to an intradermal carcinoma and is potentially malignant. Atypical squamous (resembling fish scales) cells proliferate through the whole thickness of the epidermis. The lesions may occur anywhere on the skin surface or on mucosal surfaces. The cause most frequently found is trivalent arsenic compounds. Freezing, cauterization or diathermy coagulation is often effective treatment.
Histology
Bowen's is equivalent to squamous cell carcinoma in situ. The entire tumor is confined to the epidermis and does not invade into the dermis. The cells in Bowen's are extremely unusual or atypical under the microscope and in many cases look worse under the microscope than the cells of many outright and invading squamous-cell carcinomas. Microscopy is the technical field of using microscopes to view samples or objects The degree of atypia (strangeness, unusualness) seen under the microscope best tells how cells may behave should they invade another portion of the body. Atypia is a clinical term for abnormality in a cell The term is medical jargon for an atypical cell
Treatment
Photodynamic therapy (PDT), Cryotherapy (freezing) or local chemotherapy (with 5-fluorouracil) are favored by some clinicians over excision. Photodynamic therapy (PDT matured as a feasible medical technology in the 1980s at several institutions throughout the world is a third-level treatment for Cancer involving Cryosurgery (cryotherapy is the application of extreme cold to destroy abnormal or diseased tissue Fluorouracil (5-FU or f5U is a Pyrimidine analog, which is used as a drug in the treatment of Cancer. Because the cells of Bowen's disease have not invaded the dermis, it has a much better prognosis than invasive squamous cell carcinoma.
External links
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