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B-cell translocation gene 1, anti-proliferative
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| Identifiers | ||
| Symbol(s) | BTG1; | |
| External IDs | OMIM: 109580 MGI: 88215 HomoloGene: 37521 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 694 | 12226 |
| Ensembl | ENSG00000133639 | n/a |
| Uniprot | P62324 | n/a |
| Refseq | NM_001731 (mRNA) NP_001722 (protein) |
NM_007569 (mRNA) NP_031595 (protein) |
| Location | Chr 12: 91.06 - 91.06 Mb | n/a |
| Pubmed search | [1] | [2] |
B-cell translocation gene 1, anti-proliferative, also known as BTG1, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
The BTG1 gene locus has been shown to be involved in a t(8;12)(q24;q22) chromosomal translocation in a case of B-cell chronic lymphocytic leukemia. It is a member of a family of antiproliferative genes. BTG1 expression is maximal in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. It negatively regulates cell proliferation. [1]
References
Further reading
- Rouault JP, Rimokh R, Tessa C, et al. (1992). "BTG1, a member of a new family of antiproliferative genes. ". EMBO J. 11 (4): 1663-70. PMID 1373383.
- Rimokh R, Rouault JP, Wahbi K, et al. (1991). "A chromosome 12 coding region is juxtaposed to the MYC protooncogene locus in a t(8;12)(q24;q22) translocation in a case of B-cell chronic lymphocytic leukemia. ". Genes Chromosomes Cancer 3 (1): 24-36. PMID 2069907.
- Lin WJ, Gary JD, Yang MC, et al. (1996). "The mammalian immediate-early TIS21 protein and the leukemia-associated BTG1 protein interact with a protein-arginine N-methyltransferase. ". J. Biol. Chem. 271 (25): 15034-44. PMID 8663146.
- Corjay MH, Kearney MA, Munzer DA, et al. (1998). "Antiproliferative gene BTG1 is highly expressed in apoptotic cells in macrophage-rich areas of advanced lesions in Watanabe heritable hyperlipidemic rabbit and human. ". Lab. Invest. 78 (7): 847-58. PMID 9690562.
- Bogdan JA, Adams-Burton C, Pedicord DL, et al. (1999). "Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1. ". Biochem. J. 336 ( Pt 2): 471-81. PMID 9820826.
- Prévôt D, Voeltzel T, Birot AM, et al. (2000). "The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation. ". J. Biol. Chem. 275 (1): 147-53. PMID 10617598.
- Prévôt D, Morel AP, Voeltzel T, et al. (2001). "Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway. ". J. Biol. Chem. 276 (13): 9640-8. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11136725.
- Rodier A, Rochard P, Berthet C, et al. (2001). "Identification of functional domains involved in BTG1 cell localization. ". Oncogene 20 (21): 2691-703. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11420681.
- Yoshida Y, Hosoda E, Nakamura T, Yamamoto T (2001). "Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex. ". Jpn. J. Cancer Res. 92 (6): 592-6. PMID 11429045.
- Berthet C, Guéhenneux F, Revol V, et al. (2002). "Interaction of PRMT1 with BTG/TOB proteins in cell signalling: molecular analysis and functional aspects. ". Genes Cells 7 (1): 29-39. PMID 11856371.
- Sasajima H, Nakagawa K, Yokosawa H (2002). "Antiproliferative proteins of the BTG/Tob family are degraded by the ubiquitin-proteasome system. ". Eur. J. Biochem. 269 (14): 3596-604. PMID 12135500.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ". Proc. Natl. Acad. Sci. U. S. A. 99 (26): 16899-903. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12477932.
- Bakker WJ, Blázquez-Domingo M, Kolbus A, et al. (2004). "FoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1. ". J. Cell Biol. 164 (2): 175-84. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 14734530.
- Iwai K, Hirata K, Ishida T, et al. (2004). "An anti-proliferative gene BTG1 regulates angiogenesis in vitro. ". Biochem. Biophys. Res. Commun. 316 (3): 628-35. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15033446.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ". Genome Res. 14 (10B): 2121-7. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15489334.
- Busson M, Carazo A, Seyer P, et al. (2005). "Coactivation of nuclear receptors and myogenic factors induces the major BTG1 influence on muscle differentiation. ". Oncogene 24 (10): 1698-710. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15674337.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network. ". Nature 437 (7062): 1173-8. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16189514.
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