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Bone marrow stromal cell antigen 2
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| Identifiers | ||
| Symbol(s) | BST2; CD317 | |
| External IDs | OMIM: 600534 MGI: 1916800 HomoloGene: 48277 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 684 | 69550 |
| Ensembl | ENSG00000130303 | ENSMUSG00000046718 |
| Uniprot | Q10589 | Q8R2Q8 |
| Refseq | NM_004335 (mRNA) NP_004326 (protein) |
NM_198095 (mRNA) NP_932763 (protein) |
| Location | Chr 19: 17.37 - 17.38 Mb | Chr 8: 74.46 - 74.47 Mb |
| Pubmed search | [1] | [2] |
Bone marrow stromal cell antigen 2, also known as BST2, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1] BST2 has also been designated as CD317 (cluster of differentiation 317). The cluster of differentiation (often abbreviated as CD) is a protocol used for the identification and investigation of Cell surface molecules present on Leukocytes
Bone marrow stromal cells are involved in the growth and development of B-cells. The specific function of the protein encoded by the bone marrow stromal cell antigen 2 is undetermined; however, this protein may play a role in pre-B-cell growth and in rheumatoid arthritis. [1]
References
Further reading
- Ishikawa J, Kaisho T, Tomizawa H, et al. (1995). "Molecular cloning and chromosomal mapping of a bone marrow stromal cell surface gene, BST2, that may be involved in pre-B-cell growth. ". Genomics 26 (3): 527-34. PMID 7607676.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. ". Gene 138 (1-2): 171-4. PMID 8125298.
- Furuya Y, Takasawa S, Yonekura H, et al. (1996). "Cloning of a cDNA encoding rat bone marrow stromal cell antigen 1 (BST-1) from the islets of Langerhans. ". Gene 165 (2): 329-30. PMID 8522202.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. ". Gene 200 (1-2): 149-56. PMID 9373149.
- Ohtomo T, Sugamata Y, Ozaki Y, et al. (1999). "Molecular cloning and characterization of a surface antigen preferentially overexpressed on multiple myeloma cells. ". Biochem. Biophys. Res. Commun. 258 (3): 583-91. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 10329429.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ". Proc. Natl. Acad. Sci. U. S. A. 99 (26): 16899-903. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12477932.
- Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. ". Oncogene 22 (21): 3307-18. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12761501.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ". Genome Res. 14 (10B): 2121-7. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15489334.
- Vidal-Laliena M, Romero X, March S, et al. (2006). "Characterization of antibodies submitted to the B cell section of the 8th Human Leukocyte Differentiation Antigens Workshop by flow cytometry and immunohistochemistry. ". Cell. Immunol. 236 (1-2): 6-16. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16157322.
- Elortza F, Mohammed S, Bunkenborg J, et al. (2006). "Modification-specific proteomics of plasma membrane proteins: identification and characterization of glycosylphosphatidylinositol-anchored proteins released upon phospholipase D treatment. ". J. Proteome Res. 5 (4): 935-43. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16602701.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain. Medical Subject Headings ( MeSH) is a huge Controlled vocabulary (or metadata system for the purpose of indexing journal articles and books The United States National Library of Medicine ( NLM) operated by the United States federal government, is the world's largest Medical library. The public domain is a range of abstract materials &ndash commonly referred to as Intellectual property &ndash which are not owned or controlled by anyone
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