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B lymphoid tyrosine kinase
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| Identifiers | ||
| Symbol(s) | BLK; MGC10442 | |
| External IDs | OMIM: 191305 MGI: 88169 HomoloGene: 1297 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 640 | 12143 |
| Ensembl | ENSG00000136573 | ENSMUSG00000014453 |
| Uniprot | P51451 | Q3TAT8 |
| Refseq | NM_001715 (mRNA) NP_001706 (protein) |
NM_007549 (mRNA) NP_031575 (protein) |
| Location | Chr 8: 11.39 - 11.46 Mb | Chr 14: 62.33 - 62.37 Mb |
| Pubmed search | [1] | [2] |
B lymphoid tyrosine kinase, also known as BLK, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
References
Further reading
- Dymecki SM, Niederhuber JE, Desiderio SV (1990). "Specific expression of a tyrosine kinase gene, blk, in B lymphoid cells. ". Science 247 (4940): 332–6. PMID 2404338.
- Lin YH, Shin EJ, Campbell MJ, Niederhuber JE (1995). "Transcription of the blk gene in human B lymphocytes is controlled by two promoters. ". J. Biol. Chem. 270 (43): 25968–75. PMID 7592787.
- Saouaf SJ, Kut SA, Fargnoli J, et al. (1995). "Reconstitution of the B cell antigen receptor signaling components in COS cells. ". J. Biol. Chem. 270 (45): 27072–8. PMID 7592958.
- Islam KB, Rabbani H, Larsson C, et al. (1995). "Molecular cloning, characterization, and chromosomal localization of a human lymphoid tyrosine kinase related to murine Blk. ". J. Immunol. 154 (3): 1265–72. PMID 7822795.
- Drebin JA, Hartzell SW, Griffin C, et al. (1995). "Molecular cloning and chromosomal localization of the human homologue of a B-lymphocyte specific protein tyrosine kinase (blk). ". Oncogene 10 (3): 477–86. PMID 7845672.
- Donovan JA, Wange RL, Langdon WY, Samelson LE (1994). "The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor. ". J. Biol. Chem. 269 (37): 22921–4. PMID 8083187.
- Pleiman CM, Clark MR, Gauen LK, et al. (1993). "Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase. ". Mol. Cell. Biol. 13 (9): 5877–87. PMID 8395016.
- Malek SN, Yang CH, Earnshaw WC, et al. (1996). "p150TSP, a conserved nuclear phosphoprotein that contains multiple tetratricopeptide repeats and binds specifically to SH2 domains. ". J. Biol. Chem. 271 (12): 6952–62. PMID 8636124.
- Bewarder N, Weinrich V, Budde P, et al. (1996). "In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation. ". Mol. Cell. Biol. 16 (9): 4735–43. PMID 8756631.
- Saouaf SJ, Wolven A, Resh MD, Bolen JB (1997). "Palmitylation of Src family tyrosine kinases regulates functional interaction with a B cell substrate. ". Biochem. Biophys. Res. Commun. 234 (2): 325–9. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 9177269.
- Hegde R, Srinivasula SM, Ahmad M, et al. (1998). "Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist. ". J. Biol. Chem. 273 (14): 7783–6. PMID 9525867.
- Oda H, Kumar S, Howley PM (1999). "Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination. ". Proc. Natl. Acad. Sci. U. S. A. 96 (17): 9557–62. PMID 10449731.
- Appel S, Filter M, Reis A, et al. (2002). "Physical and transcriptional map of the critical region for keratolytic winter erythema (KWE) on chromosome 8p22-p23 between D8S550 and D8S1759. ". Eur. J. Hum. Genet. 10 (1): 17–25. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11896452.
- Lee S, Ha S, Chung M, et al. (2003). "Mouse DAM1 regulates pro-apoptotic activity of BLK in mammary epithelial cells. ". Cancer Lett. 188 (1-2): 121–6. PMID 12406557.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ". Proc. Natl. Acad. Sci. U. S. A. 99 (26): 16899–903. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12477932.
- Cho JY, Akbarali Y, Zerbini LF, et al. (2004). "Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene. ". J. Biol. Chem. 279 (19): 19512–22. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 14970218.
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