Aralkylamine N-acetyltransferase

In enzymology, an aralkylamine N-acetyltransferase (EC 2.3.1.87) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + a 2-arylethylamine $\rightleftharpoons$ CoA + an N-acetyl-2-arylethylamine

Thus, the two substrates of this enzyme are acetyl-CoA and 2-arylethylamine, whereas its two products are CoA and N-acetyl-2-arylethylamine. Enzymes are Biomolecules that catalyze ( ie increase the rates of Chemical reactions Almost all enzymes are Proteins This article is about the Enzyme Commission codes For the European Commission system for coding chemicals see EC-No. Enzymes are Biomolecules that catalyze ( ie increase the rates of Chemical reactions Almost all enzymes are Proteins Catalysis is the process in which the rate of a Chemical reaction is increased by means of a Chemical substance known as a catalyst A chemical reaction is a process that always results in the interconversion of Chemical substances The substance or substances initially involved in a chemical reaction are called Acetyl-CoA is an important molecule in metabolism used in many biochemical reactions A product is a substance that forms as a result of a Biological - or Chemical reaction. Coenzyme A ( CoA, CoASH, or HSCoA) is a Coenzyme, notable for its role in the synthesis and oxidation of Fatty acids

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. In Biochemistry, a transferase is an Enzyme that catalyzes the transfer of a Functional group (e Acyltransferase is a type of Transferase Enzyme which acts upon Acyl groups The systematic name of this enzyme class is acetyl-CoA:2-arylethylamine N-acetyltransferase. Other names in common use include serotonin acetyltransferase, serotonin acetylase, arylalkylamine N-acetyltransferase, serotonin N-acetyltransferase, AANAT, and melatonin rhythm enzyme. This enzyme participates in tryptophan metabolism. Tryptophan (abbreviated as Trp or W) is one of the 20 standard amino acids, as well as an Essential amino acid in the Human diet

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1B6B, 1IB1, 1KUV, 1KUX, 1KUY, and 1L0C. In Biochemistry and Chemistry, the tertiary structure of a Protein or any other Macromolecule is its three-dimensional structure as defined The Protein Data Bank ( PDB) is a repository for 3-D structural data of Proteins and Nucleic acids These data typically obtained by X-ray crystallography

References

IUBMB entry for 2.3.1.87
BRENDA references for 2.3.1.87 (Recommended. )
PubMed references for 2.3.1.87
PubMed Central references for 2.3.1.87
Google Scholar references for 2.3.1.87
Voisin P, Namboodiri MA, Klein DC (1984). "Arylamine N-acetyltransferase and arylalkylamine N-acetyltransferase in the mammalian pineal gland". J. Biol. Chem. 259: 10913–8. PMID 6469990.
Fauchere JL, Boutin JA (2000). "Substrate specificity and inhibition studies of human serotonin N-acetyltransferase". J. Biol. Chem. 275: 8794–805. doi:10.1074/jbc.275.12.8794. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 10722724.
Khalil EM and Cole PA (1998). "A potent inhibitor of the melatonin rhythm enzyme". J. Am. Chem. Soc. 120: 6195–6196. doi:10.1021/ja981365a. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document.

External links

The CAS registry number for this enzyme class is 92941-56-5. CAS registry numbers are unique numerical identifiers for Chemical compounds Polymers biological sequences mixtures and Alloys They are also referred to