Anti-cholesterol is a naturally occurring antibody to cholesterol produced by mammals. Antibodies (also known as immunoglobulins, abbreviated Ig) are Gamma globulin Proteins that are found in Blood or other Bodily Cholesterol is a Lipid found in the Cell membranes and transported in the Blood plasma of all Animals It is an essential component of mammalian It is believed that this antibody serves a ‘housekeeping’ or protective role for the host animal, helping to protect the animal from harmful forms of cholesterol such as LDL and VLDL. Low-density lipoprotein ( LDL) is a type of Lipoprotein that transports Cholesterol and Triglycerides from the Liver to peripheral
Modes of Action
An immunoglobulin protein, anti-cholesterol may be found both in circulation as well as in the digestive tract.
- In circulation, this antibody binds selectively to the small, dense, oxidized cholesterol-rich LDL particles that are known to contribute to the development of atherosclerosis. Atherosclerosis is a Disease affecting arterial Blood vessels It is a chronic inflammatory response in the walls of arteries in large part due to the accumulation The antibody does not bind the good forms of cholesterol such as HDL.
- In the gastrointestinal tract, the antibody acts as a cholesterol absorption inhibitor. Cholesterol absorption inhibitors are a class of compounds that prevents the uptake of Cholesterol from the small intestine into the circulatory system The antibody selectively binds to cholesterol-rich micelles and prevents their uptake by the intestinal enterocyte. A micelle (rarely micella, plural micelles) is an aggregate of Surfactant molecules dispersed in a liquid Colloid. Enterocytes, or intestinal absorptive cells, are Simple columnar Epithelial cells found in the Small intestines and Colon. The antibody-bound micelle is then removed through fecal clearance.
References
- Interaction of anti-cholesterol antibodies with human lipoproteins. Dijkstra J, Swartz GM Jr, Raney JJ, Aniagolu J, Toro L, Nacy CA, Green SJ. J Immunol. 1996 Sep 1;157(5):2006-13.
- Immunization with cholesterol-rich liposomes induces anti-cholesterol antibodies and reduces diet-induced hypercholesterolemia and plaque formation. Alving CR, Swartz GM Jr, Wassef NM, Ribas JL, Herderick EE, Virmani R, Kolodgie FD, Matyas GR, Cornhill JF. J Lab Clin Med. 1996 Jan;127(1):40-9.
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