 |
|
|
Adapalene
|
|
| Systematic (IUPAC) name | |
| 6-[3-(1-adamantyl)-4-methoxy-phenyl] naphthalene-2-carboxylic acid | |
| Identifiers | |
| CAS number | |
| ATC code | D10 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C28H28O3 |
| Mol. mass | 412. IUPAC Nomenclature is a system of naming Chemical compounds and of describing the science of Chemistry in general CAS registry numbers are unique numerical identifiers for Chemical compounds Polymers biological sequences mixtures and Alloys They are also referred to The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs It is controlled by the WHO Collaborating Centre for Drug A section of the Anatomical Therapeutic Chemical Classification System. PubChem is a Database of chemical Molecules The system is maintained by the National Center for Biotechnology Information (NCBI a component The DrugBank database available at the University of Alberta is a unique Bioinformatics and Cheminformatics resource that combines detailed drug (i A chemical formula is a way of expressing information about the Atoms that constitute a particular Chemical compound, and how the relationship between those atoms changes Carbon (kɑɹbən is a Chemical element with the symbol C and its Atomic number is 6 Hydrogen (ˈhaɪdrədʒən is the Chemical element with Atomic number 1 Oxygen (from the Greek roots ὀξύς (oxys (acid literally "sharp" from the taste of acids and -γενής (-genēs (producer literally begetteris the The molecular mass (abbreviated m of a substance, more commonly referred to as molecular weight and abbreviated as MW, is the Mass of one 52 g/mol |
| Pharmacokinetic data | |
| Bioavailability | Very low |
| Metabolism | ? |
| Half life | ? |
| Excretion | Biliary |
| Therapeutic considerations | |
| Pregnancy cat. |
C |
| Legal status | |
| Routes | Topical |
Adapalene is a topical retinoid primarily used in the treatment of acne and is also used (off-label) to treat keratosis pilaris as well as other skin conditions. In Pharmacology, bioavailability is used to describe the fraction of an administered Dose of unchanged drug that reaches the Systemic circulation, one of Drug metabolism is the Metabolism of drugs, their Biochemical modification or degradation usually through specialized enzymatic systems The biological half-life of a substance is the time it takes for a substance (drug radioactive nuclide or other to lose half of its pharmacologic physiologic or radiologic activity Excretion is the process of eliminating waste products of Metabolism and other non-useful materials A bile duct is any of a number of long tube-like structures that carry Bile. The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical if it is used as directed by the mother during The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction A prescription drug is a licensed medicine that is regulated by legislation to require a prescription before it can be obtained The United Kingdom of Great Britain and Northern Ireland, commonly known as the United Kingdom, the UK or Britain,is a Sovereign state located A prescription drug is a licensed medicine that is regulated by legislation to require a prescription before it can be obtained The United States of America —commonly referred to as the In Pharmacology and Toxicology, a route In Medicine, a topical Medication is applied to body surfaces such as the Skin or Mucous membranes for example the Vagina The retinoids are a class of Chemical compounds that are related chemically to Vitamin A. Acne vulgaris (commonly called acne) is a Skin disease caused by changes in the Pilosebaceous units (skin structures consisting of a Hair follicle Off-label use is the practice of prescribing drugs for a purpose outside the scope of the drug's approved label most often concerning the drug's indication. Keratosis pilaris (KP also follicular keratosis is a very common genetic follicular condition that is manifested by the appearance of rough bumps on the skin [1] It is currently marketed by Galderma under the trade names Differin in some countries, and Adaferin in India. Galderma is an international pharmaceutical company specializing in the research development and marketing of therapeutic corrective and aesthetic solutions for Dermatology patients
Contents |
Indications
Adapalene is indicated for the topical treatment of acne vulgaris. Acne vulgaris (commonly called acne) is a Skin disease caused by changes in the Pilosebaceous units (skin structures consisting of a Hair follicle
Adapalene has been shown to enhance the efficacy of topical clindamycin. Clindamycin ( rINN; klɪndəˈmaɪsɨn is a lincosamide Antibiotic. Application of adapalene gel to the skin 2-5 minutes before application of clindamycin enhances the overall efficacy of the treatment as compared to clindamycin alone.
History
Adapalene was approved in 1996 by the U. Year 1996 ( MCMXCVI) was a Leap year starting on Monday (link will display full 1996 Gregorian calendar) S. Food and Drug Administration for use in the treatment of acne.
Dosage
Adapalene is applied once daily, after washing and before retiring. In some circumstances, when a patient complains of skin irritation, this may be decreased to once every other day until the irritation ceases.
Available Forms
In the United States, adapalene is available under the brand name Differin in three different preparations: 0. The United States of America —commonly referred to as the Differin is a Trade name for a medication for Acne vulgaris made by Galderma Laboratories. 1% cream, 0. 1% gel, and 0. 3% gel. [2]
In Europe, only the 0. 1% Cream and 0. 1% Gel are available.
Pharmacology
Pharmacodynamics
Adapalene in small concentrations is a moderator of cellular differentiation, keratinization, and inflammatory processes. In Developmental biology, cellular differentiation is the process by which a less specialized cell becomes a more specialized Cell type. Keratins are a family of fibrous structural proteins; tough and insoluble they form the hard but nonmineralized structures found in Reptiles Birds The exact mode of action of adapalene is unknown.
Pharmacokinetics
Adapalene is applied topically to the skin, and its absorption into the blood through this medium is very low. Only trace amounts of adapalene have been found in the plasma of chronically treated patients.
External links
References
- ^ Rolewski S (2003). "Clinical review: topical retinoids.". Dermatol Nurs 15 (5): 447-50, 459-65. PMID 14619325.
- ^ About Differin
Dictionary
adapalene
-noun
- (pharmacology) A particular medicine used topically to treat skin conditions.
Dapyx Software network: MP3 Explorer | Ebook Manager | Zenithic