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Actin related protein 2/3 complex, subunit 1A, 41kDa
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| Identifiers | ||
| Symbol(s) | ARPC1A; Arc40; SOP2Hs; SOP2L | |
| External IDs | OMIM: 604220 MGI: 1928896 HomoloGene: 4675 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 10552 | 56443 |
| Ensembl | ENSG00000013455 | ENSMUSG00000029621 |
| Uniprot | Q92747 | Q9R0Q6 |
| Refseq | NM_006409 (mRNA) NP_006400 (protein) |
NM_019767 (mRNA) NP_062741 (protein) |
| Location | Chr 7: 98.76 - 98.8 Mb | Chr 5: 145.34 - 145.36 Mb |
| Pubmed search | [1] | [2] |
Actin related protein 2/3 complex, subunit 1A, 41kDa, also known as ARPC1A, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1B. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. [1]
References
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. ". Gene 138 (1-2): 171–4. PMID 8125298.
- Balasubramanian MK, Feoktistova A, McCollum D, Gould KL (1997). "Fission yeast Sop2p: a novel and evolutionarily conserved protein that interacts with Arp3p and modulates profilin function. ". EMBO J. 15 (23): 6426–37. PMID 8978670.
- Welch MD, DePace AH, Verma S, et al. (1997). "The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. ". J. Cell Biol. 138 (2): 375–84. PMID 9230079.
- Machesky LM, Reeves E, Wientjes F, et al. (1998). "Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins. ". Biochem. J. 328 ( Pt 1): 105–12. PMID 9359840.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. ". Gene 200 (1-2): 149–56. PMID 9373149.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ". Proc. Natl. Acad. Sci. U. S. A. 99 (26): 16899–903. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12477932.
- Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology. ". Science 300 (5620): 767–72. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12690205.
- Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7. ". Nature 424 (6945): 157–64. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12853948.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ". Genome Res. 14 (10B): 2121–7. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15489334.
- Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics. ". Nature 433 (7021): 77–83. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15635413.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry. ". Mol. Syst. Biol. 3: 89. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 17353931.
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