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Acyl-CoA synthetase long-chain family member 1
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| Identifiers | ||
| Symbol(s) | ACSL1; ACS1; FACL1; FACL2; LACS; LACS1; LACS2 | |
| External IDs | OMIM: 152425 MGI: 102797 HomoloGene: 37561 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 2180 | 14081 |
| Ensembl | ENSG00000151726 | ENSMUSG00000018796 |
| Uniprot | P33121 | Q6GTG6 |
| Refseq | NM_001995 (mRNA) NP_001986 (protein) |
XM_991183 (mRNA) XP_996277 (protein) |
| Location | Chr 4: 185.91 - 185.98 Mb | Chr 8: 47.97 - 48.03 Mb |
| Pubmed search | [1] | [2] |
Acyl-CoA synthetase long-chain family member 1, also known as ACSL1, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. [1]
References
Further reading
- Stanczak H, Stanczak JJ, Singh I (1992). "Chromosomal localization of the human gene for palmitoyl-CoA ligase (FACL1). ". Cytogenet. Cell Genet. 59 (1): 17–9. PMID 1531127.
- Amigo L, McElroy MC, Morales MN, Bronfman M (1992). "Subcellular distribution and characteristics of ciprofibroyl-CoA synthetase in rat liver. Its possible identity with long-chain acyl-CoA synthetase. ". Biochem. J. 284 ( Pt 1): 283–7. PMID 1599407.
- Abe T, Fujino T, Fukuyama R, et al. (1992). "Human long-chain acyl-CoA synthetase: structure and chromosomal location. ". J. Biochem. 111 (1): 123–8. PMID 1607358.
- Lageweg W, Wanders RJ, Tager JM (1991). "Long-chain-acyl-CoA synthetase and very-long-chain-acyl-CoA synthetase activities in peroxisomes and microsomes from rat liver. An enzymological study. ". Eur. J. Biochem. 196 (2): 519–23. PMID 2007410.
- Suzuki H, Kawarabayasi Y, Kondo J, et al. (1990). "Structure and regulation of rat long-chain acyl-CoA synthetase. ". J. Biol. Chem. 265 (15): 8681–5. PMID 2341402.
- Singh I, Bhushan A, Relan NK, Hashimoto T (1989). "Acyl-CoA ligases from rat brain microsomes: an immunochemical study. ". Biochim. Biophys. Acta 963 (3): 509–14. PMID 2973813.
- Bierbach H (1981). "Studies on long chain fatty acid:CoA ligase from human small intestine. ". Gut 21 (8): 689–94. PMID 7429333.
- Cantú ES, Sprinkle TJ, Ghosh B, Singh I (1996). "The human palmitoyl-CoA ligase (FACL2) gene maps to the chromosome 4q34-q35 region by fluorescence in situ hybridization (FISH) and somatic cell hybrid panels. ". Genomics 28 (3): 600–2. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 7490105.
- Wu P, Bremer J (1994). "Activation of alkylthioacrylic acids in subcellular fractions of rat tissues: a new spectrophotometric method for assay of acyl-CoA synthetase. ". Biochim. Biophys. Acta 1215 (1-2): 87–92. PMID 7948012.
- Singh I, Lazo O, Kremser K (1993). "Purification of peroxisomes and subcellular distribution of enzyme activities for activation and oxidation of very-long-chain fatty acids in rat brain. ". Biochim. Biophys. Acta 1170 (1): 44–52. PMID 8399326.
- Ghosh B, Barbosa E, Singh I (1996). "Molecular cloning and sequencing of human palmitoyl-CoA ligase and its tissue specific expression. ". Mol. Cell. Biochem. 151 (1): 77–81. PMID 8584017.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery. ". Genome Res. 6 (9): 791–806. PMID 8889548.
- Malhotra KT, Malhotra K, Lubin BH, Kuypers FA (2000). "Identification and molecular characterization of acyl-CoA synthetase in human erythrocytes and erythroid precursors. ". Biochem. J. 344 Pt 1: 135–43. PMID 10548543.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ". Proc. Natl. Acad. Sci. U. S. A. 99 (26): 16899–903. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs. ". Nat. Genet. 36 (1): 40–5. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 14702039.
- Mashek DG, Bornfeldt KE, Coleman RA, et al. (2005). "Revised nomenclature for the mammalian long-chain acyl-CoA synthetase gene family. ". J. Lipid Res. 45 (10): 1958–61. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15292367.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ". Genome Res. 14 (10B): 2121–7. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15489334.
- Soupene E, Kuypers FA (2006). "Multiple erythroid isoforms of human long-chain acyl-CoA synthetases are produced by switch of the fatty acid gate domains. ". BMC Mol. Biol. 7: 21. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16834775.
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