|
V-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)
|
||
 |
||
| PDB rendering based on 1ab2. The Protein Data Bank ( PDB) is a repository for 3-D structural data of Proteins and Nucleic acids These data typically obtained by X-ray crystallography | ||
| Available structures: 1ab2, 1abo, 1abq, 1bbz, 1fpu, 1iep, 1ju5, 1m52, 1opj, 2e2b, 2f4j, 2g1t, 2g2f, 2g2h, 2g2i, 2gqg, 2hiw, 2hyy, 2hz0, 2hz4, 2hzi, 2hzn | ||
| Identifiers | ||
| Symbol(s) | ABL2; ABLL; ARG | |
| External IDs | OMIM: 164690 MGI: 87860 HomoloGene: 5278 | |
| RNA expression pattern | ||
|
|
||
| Orthologs | ||
| Human | Mouse | |
| Entrez | 27 | 11352 |
| Ensembl | ENSG00000143322 | ENSMUSG00000026596 |
| Uniprot | P42684 | Q61055 |
| Refseq | NM_005158 (mRNA) NP_005149 (protein) |
NM_009595 (mRNA) NP_033725 (protein) |
| Location | Chr 1: 177.34 - 177.47 Mb | Chr 1: 158.4 - 158.48 Mb |
| Pubmed search | [1] | [2] |
V-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene), also known as ABL2, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
ABL2 is a cytoplasmic tyrosine kinase which is closely related to but distinct from ABL1. The similarity of the proteins includes the tyrosine kinase domains and extends amino-terminal to include the SH2 and SH3 domains. ABL2 is expressed in both normal and tumor cells. The ABL2 gene product is expressed as two variants bearing different amino termini, both approximately 12-kb in length. [1]
References
Further reading
- Pendergast AM (2003). "The Abl family kinases: mechanisms of regulation and signaling. ". Adv. Cancer Res. 85: 51–100. PMID 12374288.
- Muller AJ, Pendergast AM, Havlik MH, et al. (1992). "A limited set of SH2 domains binds BCR through a high-affinity phosphotyrosine-independent interaction. ". Mol. Cell. Biol. 12 (11): 5087–93. PMID 1383690.
- Kruh GD, Perego R, Miki T, Aaronson SA (1990). "The complete coding sequence of arg defines the Abelson subfamily of cytoplasmic tyrosine kinases. ". Proc. Natl. Acad. Sci. U. S. A. 87 (15): 5802–6. PMID 2198571.
- Kruh GD, King CR, Kraus MH, et al. (1987). "A novel human gene closely related to the abl proto-oncogene. ". Science 234 (4783): 1545–8. PMID 3787260.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. ". Gene 138 (1-2): 171–4. PMID 8125298.
- Wang B, Kruh GD (1996). "Subcellular localization of the Arg protein tyrosine kinase. ". Oncogene 13 (1): 193–7. PMID 8700546.
- Wang B, Mysliwiec T, Feller SM, et al. (1996). "Proline-rich sequences mediate the interaction of the Arg protein tyrosine kinase with Crk. ". Oncogene 13 (7): 1379–85. PMID 8875975.
- Wang B, Golemis EA, Kruh GD (1997). "ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks. ". J. Biol. Chem. 272 (28): 17542–50. PMID 9211900.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. ". Gene 200 (1-2): 149–56. PMID 9373149.
- Koval AP, Blakesley VA, Roberts CT, et al. (1998). "Interaction in vitro of the product of the c-Crk-II proto-oncogene with the insulin-like growth factor I receptor. ". Biochem. J. 330 ( Pt 2): 923–32. PMID 9480911.
- Hashimoto Y, Katayama H, Kiyokawa E, et al. (1998). "Phosphorylation of CrkII adaptor protein at tyrosine 221 by epidermal growth factor receptor. ". J. Biol. Chem. 273 (27): 17186–91. PMID 9642287.
- Danial NN, Losman JA, Lu T, et al. (1998). "Direct interaction of Jak1 and v-Abl is required for v-Abl-induced activation of STATs and proliferation. ". Mol. Cell. Biol. 18 (11): 6795–804. PMID 9774693.
- Cao C, Ren X, Kharbanda S, et al. (2001). "The ARG tyrosine kinase interacts with Siva-1 in the apoptotic response to oxidative stress. ". J. Biol. Chem. 276 (15): 11465–8. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11278261.
- Yu HH, Zisch AH, Dodelet VC, Pasquale EB (2001). "Multiple signaling interactions of Abl and Arg kinases with the EphB2 receptor. ". Oncogene 20 (30): 3995–4006. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11494128.
- Endo A, Nagashima K, Kurose H, et al. (2002). "Sphingosine 1-phosphate induces membrane ruffling and increases motility of human umbilical vein endothelial cells via vascular endothelial growth factor receptor and CrkII. ". J. Biol. Chem. 277 (26): 23747–54. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11956190.
- Abassi YA, Vuori K (2002). "Tyrosine 221 in Crk regulates adhesion-dependent membrane localization of Crk and Rac and activation of Rac signaling. ". EMBO J. 21 (17): 4571–82. PMID 12198159.
- Bianchi C, Muradore I, Corizzato M, et al. (2002). "The expression of the non-receptor tyrosine kinases Arg and c-abl is differently modulated in B lymphoid cells at different stages of differentiation. ". FEBS Lett. 527 (1-3): 216–222. PMID 12220663.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ". Proc. Natl. Acad. Sci. U. S. A. 99 (26): 16899–903. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12477932.
- Salomon AR, Ficarro SB, Brill LM, et al. (2003). "Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. ". Proc. Natl. Acad. Sci. U. S. A. 100 (2): 443–8. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12522270.
Dapyx Software network: MP3 Explorer | Ebook Manager | Zenithic